Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | STK17B | O94768 | 6/20 | 0.55 |
| ▸ | MAP3K8 | P41279 | 4/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16281232 | 0.84 | IKBKB (0.67) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL15703493 | 0.81 | MAP3K8 (0.55) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL14090791 | 0.81 | RAB9A (0.52) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL17268775 | 0.78 | NPC1 (0.72) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL15721691 | 0.76 | MAP3K8 (0.56) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL15504606 | 0.72 | RAB9A (0.68) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL15703517 | 0.72 | NPC1 (1.00) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL3979017 | 0.71 | NPC1 (0.67) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL2879120 | 0.71 | NPC1 (0.67) | RAB9ANPC1KMT2ATDP1STK17B | |
| SCHEMBL13313005 | 0.71 | MCHR1 (0.57) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160243085-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | MIDCAP FINANCIAL TRUST | 2016-08-25 | — | — | US | disclosed |
| US-9353126-B2 | Substituted triazoles useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| EP-2476679-B1 | Substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC (US) | 2015-10-14 | — | — | EP | disclosed |
| US-20150072959-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | MIDCAP FINANCIAL TRUST | 2015-03-12 | — | — | US | disclosed |
| US-8906922-B2 | Substituted triazoles useful as AXl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2014-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072959-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, MERTK | RAB9A 2200/4885NPC1 4152/4885KMT2A 2917/4885 |
| US-20160243085-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, MERTK | RAB9A 2200/4885NPC1 4152/4885KMT2A 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.