Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16281527 | 0.73 | LMNA (0.50) | LMNASMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL21794553 | 0.69 | GAA (0.33) | EGFRERBB2ALDH1A1HTTHPGD | |
| SCHEMBL15166759 | 0.67 | LMNA (0.47) | LMNAEGFRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL15166678 | 0.66 | LMNA (0.46) | LMNASMN1; SMN2KDM4EMAPTCYP2D6 | |
| SCHEMBL16281522 | 0.66 | LMNA (0.41) | LMNASMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL15170632 | 0.65 | LMNA (0.45) | LMNASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL15170544 | 0.64 | LMNA (0.44) | LMNACYP2D6 | |
| SCHEMBL15170462 | 0.63 | LMNA (0.40) | LMNASMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL16281525 | 0.62 | LMNA (0.39) | LMNAKDM4ECYP2D6HPGD | |
| SCHEMBL19633609 | 0.61 | IRAK4 (0.47) | EGFRKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2810944-A1 | HETEROCYCLIC COMPOUND HAVING ANTI-HIV ACTIVITY | Toyama Chemical Co., Ltd. (JP) | 2014-12-10 | — | — | EP | disclosed |