Sugi Predict

Sugi Predict / Compounds / SCHEMBL1628561

SCHEMBL1628561

SCHEMBL1628561

COC(=O)CNC(=O)C1=C(O)c2cc(Cl)ccc2C2(CCN(C(=O)c3ccccc3)CC2)C1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SPR P35270 1/20 0.45
▸ IP6K1 Q92551 5/20 0.40
▸ NPC1L1 Q9UHC9 2/20 0.39
▸ EGLN1 Q9GZT9 2/20 0.39
▸ CHRM2 P08172 1/20 0.38
▸ CHRM3 P20309 1/20 0.38
▸ IP6K3 Q96PC2 1/20 0.38
▸ IP6K2 Q9UHH9 1/20 0.38
▸ EPHX2 P34913 1/20 0.37
▸ CCR8 P51685 2/20 0.37
▸ KCNH2 Q12809 2/20 0.37
▸ ALDH1A1 P00352 3/20 0.36
▸ MAPK1 P28482 2/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ OPRD1 P41143 2/20 0.36
▸ OPRK1 P41145 1/20 0.36
▸ LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12720490 0.91 SPR (0.42) SPRIP6K1CHRM2CHRM3IP6K3
SCHEMBL1627424 0.91 SPR (0.42) SPRIP6K1EGLN1CHRM2CHRM3
SCHEMBL1626639 0.85 SPR (0.46) SPREGLN1SMN1; SMN2OPRD1OPRK1
SCHEMBL1626661 0.82 SPR (0.52) SPREGLN1CHRM3ALDH1A1HPGD
SCHEMBL1627956 0.82 SPR (0.50) SPREGLN1ALDH1A1SMN1; SMN2VEGFA
SCHEMBL1626962 0.80 NPFFR1 (0.42) SPRCCR8KCNH2
SCHEMBL12720469 0.78 SPR (0.43) SPRCHRM2CHRM3ALDH1A1SMN1; SMN2
SCHEMBL1625788 0.78 SPR (0.42) SPREGLN1CHRM2CHRM3
SCHEMBL1626977 0.77 SPR (0.48) SPREGLN1ALDH1A1
SCHEMBL1626261 0.77 SPR (0.48) SPREGLN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7928139-B2 Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof AMGEN INC. (US) 2011-04-19 — — US disclosed
US-20100048572-A1 NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF AMGEN INC. (US) 2010-02-25 — — US disclosed
US-7635715-B2 Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof AMGEN INC. (US) 2009-12-22 — — US disclosed
US-20090093483-A1 Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof AMGEN INC. (US) 2009-04-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048572-A1 NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF EGLN2, EGLN3, HIF1AN SPR 754/4885IP6K1 3258/4885NPC1L1 2638/4885
US-20090093483-A1 Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof EGLN2, EGLN3, HIF1AN SPR 754/4885IP6K1 3258/4885NPC1L1 2638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.