Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 4/20 | 0.46 |
| ▸ | CDK4 | P11802 | 7/20 | 0.44 |
| ▸ | CCND1 | P24385 | 7/20 | 0.44 |
| ▸ | CCND2 | P30279 | 5/20 | 0.44 |
| ▸ | CCND3 | P30281 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16286126 | 0.92 | CDK4 (0.44) | PTK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL16285679 | 0.87 | CCND3 (0.46) | CDK4CCND1CCND2CCND3CDK9 | |
| SCHEMBL16285719 | 0.84 | CDK4 (0.51) | CDK4CCND1CCND2CCND3CYP3A4 | |
| SCHEMBL16286128 | 0.82 | CDK4 (0.46) | PTK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL10192711 | 0.82 | CDK4 (0.67) | PTK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL16285699 | 0.81 | CDK4 (0.46) | PTK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL16286112 | 0.81 | PTK2 (0.45) | PTK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL16286125 | 0.80 | CDK4 (0.42) | PTK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL16286122 | 0.80 | FGFR4 (0.44) | PTK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL16285672 | 0.80 | CCND3 (0.47) | CDK4CCND1CCND2CCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364430-A1 | METHODS FOR TREATING SCHIZOPHRENIA | AFRAXIS HOLDINGS INC (US) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364430-A1 | METHODS FOR TREATING SCHIZOPHRENIA | GRIN2A, GRIN2C, GRIN3A | PTK2 476/4885CDK4 2824/4885CCND1 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.