⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28609118 | 0.76 | — | — | |
| SCHEMBL5673793 | 0.76 | NOS3 (0.33) | — | |
| SCHEMBL11507660 | 0.76 | — | — | |
| SCHEMBL283760 | 0.74 | — | — | |
| SCHEMBL12806508 | 0.74 | — | — | |
| SCHEMBL33699 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL7196448 | 0.73 | NOS3 (0.31) | — | |
| SCHEMBL13679854 | 0.73 | — | — | |
| SCHEMBL5386968 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL7637452 | 0.73 | NOS3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676429-B2 | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2020-06-09 | — | — | US | disclosed |
| EP-3114111-B1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | disclosed |
| EP-3114111-A1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | Janssen Pharmaceutica NV (BE) | 2017-01-11 | — | — | EP | disclosed |
| CN-106061943-A | Bicyclic pyrrole derivatives useful as agonists of GPR120 | 詹森药业有限公司 | 2016-10-26 | — | — | CN | disclosed |
| US-20150266890-A1 | SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2015-09-24 | — | — | US | disclosed |
| WO-2015134038-A1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-11 | — | — | WO | disclosed |
| US-8912227-B1 | Bicyclic pyrrole derivatives useful as agonists of GPR120 | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-16 | — | — | US | disclosed |