SCHEMBL16286377

SCHEMBL16286377

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(CCN)CC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 20/20 1.00
TYMS P04818 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6580678 0.94 NAMPT (0.90) NAMPTTYMS
SCHEMBL6583674 0.94 NAMPT (0.93) NAMPTTYMS
SCHEMBL31181450 0.94 NAMPT (1.00) NAMPTTYMS
SCHEMBL6584545 0.94 NAMPT (1.00) NAMPTTYMS
SCHEMBL30205388 0.94 NAMPT (1.00) NAMPTTYMS
SCHEMBL18327891 0.94 NAMPT (0.88) NAMPT
SCHEMBL6582323 0.94 NAMPT (0.91) NAMPTTYMS
SCHEMBL6580696 0.93 NAMPT (0.90) NAMPTTYMS
SCHEMBL6580609 0.92 NAMPT (0.88) NAMPTTYMS
SCHEMBL6584636 0.92 NAMPT (0.87) NAMPTTYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260027226-A1 ANTIBODY-DRUG CONJUGATES PHEON THERAPEUTICS LTD (GB) 2026-01-29 US disclosed
WO-2025149667-A1 ANTIBODY DRUG CONJUGATES AND USES THEREOF PHEON THERAPEUTICS LTD (GB) 2025-07-17 WO disclosed
EP-4554624-A1 ANTIBODY-DRUG CONJUGATES Pheon Therapeutics Ltd (GB) 2025-05-21 EP disclosed
EP-4554623-A1 ANTIBODY DRUG CONJUGATES THAT BIND CDCP1 AND USES THEREOF Pheon Therapeutics Ltd (GB) 2025-05-21 EP disclosed
CN-119836306-A Antibody drug conjugates that bind CDCP1 and uses thereof 费恩治疗有限公司 2025-04-15 CN disclosed
CN-119836305-A Antibody-drug conjugates 费恩治疗有限公司 2025-04-15 CN disclosed
US-20240382611-A1 PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES MERSANA THERAPEUTICS, INC. 2024-11-21 US disclosed
US-11964025-B2 Peptide-containing linkers for antibody-drug conjugates MERSANA THERAPEUTICS, INC. (US) 2024-04-23 US disclosed
WO-2024013724-A1 ANTIBODY-DRUG CONJUGATES PHEON THERAPEUTICS LTD (GB) 2024-01-18 WO disclosed
US-20230043447-A1 PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES MERSANA THERAPEUTICS, INC. 2023-02-09 US disclosed
US-20230021500-A1 CYSTEINE ENGINEERED ANTIBODY-DRUG CONJUGATES WITH PEPTIDE-CONTAINING LINKERS MERSANA THERAPEUTICS, INC. 2023-01-26 US disclosed
US-20160367541-A1 THERAPEUTIC AND DIAGNOSTIC METHODS ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) 2016-12-22 US disclosed
US-8912184-B1 Therapeutic and diagnostic methods ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) 2014-12-16 US disclosed
US-8912184-B1 Therapeutic and diagnostic methods ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) 2014-12-16 US disclosed
US-8912184-B1 Therapeutic and diagnostic methods ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) 2014-12-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160367541-A1 THERAPEUTIC AND DIAGNOSTIC METHODS NAMPT, NAPRT, NNT NAMPT 1/4885TYMS 219/4885
US-20230021500-A1 CYSTEINE ENGINEERED ANTIBODY-DRUG CONJUGATES WITH PEPTIDE-CONTAINING LINKERS LNPEP, DNPEP, QPCT NAMPT 2718/4885TYMS 1799/4885
US-20230043447-A1 PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES CD2BP2, DNPEP, LNPEP NAMPT 2404/4885TYMS 2449/4885
US-20240382611-A1 PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES CD2BP2, DNPEP, LNPEP NAMPT 2404/4885TYMS 2449/4885
US-11964025-B2 Peptide-containing linkers for antibody-drug conjugates CD2BP2, DNPEP, LNPEP NAMPT 2404/4885TYMS 2449/4885
US-20260027226-A1 ANTIBODY-DRUG CONJUGATES SLC3A2, MTCL3, SLC13A2 NAMPT 2551/4885TYMS 2400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.