Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628894 | 1.00 | NFE2L2 (0.42) | NFE2L2HSP90AA1KCNN4RELACYP1A1 | |
| SCHEMBL1628551 | 0.92 | CYP1A1 (0.41) | NFE2L2HSP90AA1KCNN4RELACYP1A1 | |
| SCHEMBL1628547 | 0.92 | CYP1A1 (0.41) | NFE2L2HSP90AA1KCNN4RELACYP1A1 | |
| SCHEMBL1630510 | 0.90 | NFE2L2 (0.46) | NFE2L2HSP90AA1KCNN4RELACYP1A1 | |
| SCHEMBL1630512 | 0.90 | NFE2L2 (0.46) | NFE2L2HSP90AA1KCNN4RELACYP1A1 | |
| SCHEMBL1631540 | 0.90 | CYP1A1 (0.43) | NFE2L2HSP90AA1KCNN4RELACYP1A1 | |
| SCHEMBL1631539 | 0.90 | CYP1A1 (0.43) | NFE2L2HSP90AA1KCNN4RELACYP1A1 | |
| SCHEMBL1629065 | 0.88 | NFE2L2 (0.42) | NFE2L2HSP90AA1KCNN4RELAMAPK14 | |
| SCHEMBL1629067 | 0.88 | NFE2L2 (0.42) | NFE2L2HSP90AA1KCNN4RELAMAPK14 | |
| SCHEMBL1630458 | 0.84 | HSP90AA1 (0.44) | NFE2L2HSP90AA1KCNN4MAPK14NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776346-B1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |
| US-7932401-B2 | Heat Shock Protein 90 (HSP90) inhibitors; 5-(2-hydroxy-4-methoxyphenyl)-1-(3-nitrophenyl)-1H-pyrazole for example; antitumor agent, viral diseases, transplant rejection, cystic fibrosis, angiogenesis inhibition, infectious, autoimmune, or inflammatory diseases, ischemia, chemotherapy cytoprotectant | MERCK PATENT GMBH (DE) | 2011-04-26 | — | — | US | disclosed |
| US-20080085904-A1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085904-A1 | 1,5-Diphenylpyrazoles | HSP90AB1, HSP90AA1, HSP90AB2P | NFE2L2 1367/4885HSP90AA1 2/4885KCNN4 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.