Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29269298 | 1.00 | MEN1 (0.79) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL29269467 | 1.00 | MEN1 (0.79) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11518363 | 0.98 | MEN1 (0.81) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3923314 | 0.94 | MEN1 (0.89) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11652739 | 0.92 | MEN1 (0.86) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18882713 | 0.89 | MEN1 (0.72) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3915908 | 0.89 | MEN1 (0.68) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16106143 | 0.87 | MEN1 (0.73) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7099035 | 0.87 | MEN1 (0.78) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28917678 | 0.86 | ALDH1A1 (0.60) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2813227-A1 | Compositions for treatment of cystic fibrosis and other chronic diseases | Vertex Pharmaceuticals Incorporated (US) | 2014-12-17 | — | — | EP | disclosed |