Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.83 |
| ▸ | KDM4A | O75164 | 4/20 | 0.81 |
| ▸ | KDM4B | O94953 | 4/20 | 0.81 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.81 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | KDM5C | P41229 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17716976 | 0.90 | ADORA3 (0.76) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL31361484 | 0.88 | ADORA3 (0.90) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL31361475 | 0.87 | ADORA3 (0.81) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL18997292 | 0.86 | GRM1 (1.00) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL18997305 | 0.86 | ADORA3 (0.87) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL15183181 | 0.86 | ADORA3 (0.72) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL17206089 | 0.84 | ADORA3 (0.79) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL18230323 | 0.84 | ADORA3 (0.79) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL16607180 | 0.83 | KDM4E (1.00) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL15173521 | 0.83 | ADORA3 (0.76) | ADORA3KDM4AKDM4BKDM5BGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10633369-B2 | Method of inhibiting DYRK1B | 4 SC AG (DE) | 2020-04-28 | — | — | US | disclosed |
| US-20180201606-A1 | METHOD OF INHIBITING DYRK1B | 4 SC AG (DE) | 2018-07-19 | — | — | US | disclosed |
| US-9951050-B2 | Method of inhibiting DYRK1B | 4 SC AG (DE) | 2018-04-24 | — | — | US | disclosed |
| US-20140371251-A1 | METHOD OF INHIBITING DYRK1B | 4SC DISCOVERY GMBH (DE) | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633369-B2 | Method of inhibiting DYRK1B | SMO, GLI1, GRK2 | ADORA3 1250/4885KDM4A 1538/4885KDM4B 1284/4885 |
| US-20180201606-A1 | METHOD OF INHIBITING DYRK1B | SMO, GLI1, GRK2 | ADORA3 1250/4885KDM4A 1538/4885KDM4B 1284/4885 |
| US-20140371251-A1 | METHOD OF INHIBITING DYRK1B | SMO, GLI1, GRK2 | ADORA3 1250/4885KDM4A 1538/4885KDM4B 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.