⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965258 | 0.89 | SMN1; SMN2 (0.49) | — | |
| SCHEMBL14970182 | 0.86 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL16293345 | 0.82 | — | — | |
| SCHEMBL14964935 | 0.80 | — | — | |
| SCHEMBL16293520 | 0.80 | KDM4E (0.44) | — | |
| SCHEMBL14965212 | 0.80 | — | — | |
| SCHEMBL14965228 | 0.80 | LMNA (0.47) | — | |
| SCHEMBL14965714 | 0.80 | — | — | |
| SCHEMBL16294079 | 0.79 | — | — | |
| SCHEMBL14965147 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160152634-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2016-06-02 | — | — | US | disclosed |
| US-9290511-B2 | Thieno-pyrimidines, useful as potassium channel inhibitors | XENTION LIMITED (GB) | 2016-03-22 | — | — | US | disclosed |
| US-20140371203-A1 | Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors | XENTION LIMITED (GB) | 2014-12-18 | — | — | US | disclosed |