⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2443 | 0.83 | — | — | |
| SCHEMBL22749124 | 0.77 | — | — | |
| SCHEMBL1006386 | 0.77 | — | — | |
| SCHEMBL20395897 | 0.77 | — | — | |
| SCHEMBL140788 | 0.72 | — | — | |
| SCHEMBL5468570 | 0.72 | — | — | |
| SCHEMBL3141775 | 0.72 | — | — | |
| SCHEMBL2445716 | 0.72 | — | — | |
| SCHEMBL11761205 | 0.72 | — | — | |
| SCHEMBL330407 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1047 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174979-B2 | Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2015-11-03 | — | — | US | claimed |
| EP-2351754-B1 | PHENANTHROINDOLIZIDINE COMPOUND AND NF kB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | YAKULT HONSHA KK (JP) | 2015-06-24 | — | — | EP | claimed |
| EP-2351753-B1 | PHENANTHROINDOLIZIDINE DERIVATIVE AND NF kB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | YAKULT HONSHA KK (JP) | 2015-02-11 | — | — | EP | claimed |
| US-8865742-B2 | Intermediate compounds and processes for the preparation of quinoline derivatives such as Laquinimod sodium | MAPI PHARMA LTD. (IL) | 2014-10-21 | — | — | US | claimed |
| EP-2276740-B1 | IMPROVED PROCESS FOR PREPARING QUINOLINE-3-CARBOXAMIDE DERIVATIVES | ACTAVIS GROUP PCT EHF (IS) | 2014-08-13 | — | — | EP | claimed |
| US-20140005401-A1 | Process for Preparing Quinoline-3-Carboxamide Derivatives | ACTAVIS GROUP PTC EHF (IS) | 2014-01-02 | — | — | US | claimed |
| US-8569327-B2 | Phenanthroindolizidine derivative and NFκB inhibitor containing same as active ingredient | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2013-10-29 | — | — | US | claimed |
| US-8552194-B2 | Process for preparing quinoline-3-carboxamide derivatives | ACTAVIS GROUP PTC EHF (IS) | 2013-10-08 | — | — | US | claimed |
| EP-2642855-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM | Mapi Pharma Limited (IL) | 2013-10-02 | — | — | EP | claimed |
| US-20130245065-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM | MAPI PHARMA LTD. (IL) | 2013-09-19 | — | — | US | claimed |
| US-4167569-A | ANTICOAGULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-09-11 | — | — | US | claimed |
| EP-0002895-A1 | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof, and process for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-07-11 | — | — | EP | claimed |
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | claimed |
| US-4049804-A | Novel pregnanoic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-09-20 | — | — | US | claimed |
| US-4039668-A | CORTICOID-CONTAINING INHALANTS | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-08-02 | — | — | US | claimed |
| US-4036831-A | Trimethyl siloxane steroid intermediates | STEROID DEVELOPMENT COMPANY ESTABLISHMENT (CH) | 1977-07-19 | — | — | US | claimed |
| US-4020171-A | CHEMICAL INTERMEDIATES | SAGAMI CHEMICAL RESEARCH CENTER (JA) | 1977-04-26 | — | — | US | claimed |
| US-4011315-A | 21-ACETALS AND MIXED ACETALS OF STEROIDAL 21-ALDEHYDES, INTERMEDIATES AND METHODS OF PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1977-03-08 | — | — | US | claimed |
| US-3996358-A | 21-Esters of steroidal-21-aldehyde hydrates and 21-aldehyde hemiacetals and methods of preparation | SYNTEX (U.S.A.) INC. (US) | 1976-12-07 | — | — | US | claimed |
| US-3931167-A | Process for the manufacture of 3-keto-6-azido-4,6-bis-dehydro-steroids and intermediates useful therein | SCHERING CORPORATION (US) | 1976-01-06 | — | — | US | claimed |