Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CD74 | P04233 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16305142 | 0.86 | TSHR (0.48) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17327981 | 0.85 | TSHR (0.51) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17327982 | 0.80 | TSHR (0.45) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17312335 | 0.80 | TSHR (0.59) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16296741 | 0.75 | TSHR (0.63) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL18402541 | 0.74 | TSHR (0.65) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL18402538 | 0.74 | TSHR (0.62) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16305168 | 0.74 | SMN1; SMN2 (0.36) | TSHRHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16305169 | 0.72 | EGFR (0.50) | — | |
| SCHEMBL18400008 | 0.71 | EGFR (0.43) | TSHRHTTSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014200872-A9 | PHARMACEUTICAL COMPOUNDS TARGETED BY MIF AFFINITY-TETHERED MOIETIES | RJS BIOLOGICS LLC (US) | 2015-02-05 | — | — | WO | disclosed |
| WO-2014200872-A1 | PHARMACEUTICAL COMPOUNDS TARGETED BY MIF AFFINITY-TETHERED MOIETIES | RJS BIOLOGICS LLC (US) | 2014-12-18 | — | — | WO | disclosed |