Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 5/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.31 |
| ▸ | GAK | O14976 | 2/20 | 0.31 |
| ▸ | ILK | Q13418 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | CIT | O14578 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14472635 | 0.84 | AR (0.50) | ARXDHLMNA | |
| SCHEMBL31273968 | 0.80 | AR (0.44) | ARTEAD1EGFRGAK | |
| SCHEMBL10111073 | 0.76 | TSHR (0.51) | SMN1; SMN2TSHRGAATDP1LMNA | |
| SCHEMBL9901812 | 0.74 | GAA (0.41) | ARPTPN1SMN1; SMN2TSHRGAA | |
| SCHEMBL1391449 | 0.74 | NQO1 (0.37) | — | |
| SCHEMBL31130692 | 0.73 | — | — | |
| SCHEMBL23759950 | 0.73 | CYP3A4 (0.37) | PTPN1SMN1; SMN2TSHRTDP1EGFR | |
| SCHEMBL17094719 | 0.73 | PTGDR2 (0.44) | LMNACYP3A4 | |
| SCHEMBL4749281 | 0.73 | FFAR1 (0.47) | PTPN1SMN1; SMN2TSHRGAATDP1 | |
| SCHEMBL30755347 | 0.73 | FFAR1 (0.47) | PTPN1SMN1; SMN2TSHRGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479278-B | Novel 4-amino-3- (pyrrolyl-phenoxymethyl) -thieno [3,2] pyridine-7-carboxylic acid derivatives | HOFFMAN-LA ROCHE LTD. (CH) | 2011-12-07 | — | — | CN | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2038288-B1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| CN-101479278-A | Novel 4-amino-3- (pyrrolyl-phenoxymethyl) -thieno [3,2] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| EP-2038288-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| WO-2008000697-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENO[3,2]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | UQCRB, UQCRC2, AURKB | AR 1143/4885TEAD1 1293/4885PTPN1 3280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.