Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.72 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.62 |
| ▸ | BRD4 | O60885 | 10/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.53 |
| ▸ | AR | P10275 | 3/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1629731 | 0.85 | PGR (0.69) | PGRSCN9ABRD4NR3C1NR3C2 | |
| SCHEMBL1629244 | 0.84 | PGR (1.00) | PGRSCN9ABRD4NR3C1NR3C2 | |
| SCHEMBL1630550 | 0.83 | PGR (0.78) | PGRSCN9ABRD4NR3C1NR3C2 | |
| SCHEMBL1631091 | 0.83 | PGR (0.73) | PGRSCN9ABRD4NR3C1NR3C2 | |
| SCHEMBL1629513 | 0.83 | PGR (0.67) | PGRSCN9ABRD4NR3C1NR3C2 | |
| SCHEMBL19475720 | 0.77 | SCN9A (1.00) | SCN9A | |
| SCHEMBL16651205 | 0.75 | BRD4 (1.00) | BRD4 | |
| SCHEMBL29848783 | 0.75 | BRD4 (1.00) | BRD4 | |
| SCHEMBL29848905 | 0.74 | BRD4 (1.00) | BRD4 | |
| SCHEMBL16650164 | 0.74 | BRD4 (1.00) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |