Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 5/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16296392 | 0.85 | NOTUM (0.46) | PIM1RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL16303984 | 0.80 | PIM1 (0.39) | PIM1ELANERXRAGRIN1GRIN2B | |
| SCHEMBL16303977 | 0.80 | PIM1 (0.38) | PIM1RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL16297209 | 0.78 | PIM1 (0.39) | PIM1RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL18504510 | 0.77 | PIM1 (0.46) | PIM1RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL16297115 | 0.77 | PIM1 (0.53) | PIM1RXRAGRIN1GRIN2BSCN9A | |
| SCHEMBL16296304 | 0.76 | NOTUM (0.40) | PIM1RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL16303967 | 0.76 | PIM1 (0.38) | PIM1RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL16297293 | 0.76 | HDAC8 (0.39) | PIM1RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL16303974 | 0.76 | NLRP3 (0.45) | PIM1RXRAGRIN1GRIN2BNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008055-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-04-20 | — | — | EP | claimed |
| WO-2014198592-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-18 | — | — | WO | claimed |
| EP-3008055-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198592-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-18 | — | — | WO | disclosed |