Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.62 |
| ▸ | PDE6D | O43924 | 1/20 | 0.52 |
| ▸ | PDE6A | P16499 | 1/20 | 0.52 |
| ▸ | PDE6G | P18545 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE6B | P35913 | 1/20 | 0.52 |
| ▸ | PDE6C | P51160 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.52 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16312793 | 0.88 | PDE5A (0.55) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL16298380 | 0.82 | PDE5A (0.74) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL6626596 | 0.81 | PDE5A (0.56) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL6626597 | 0.81 | PDE5A (0.56) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL16298420 | 0.80 | TSHR (0.50) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16298474 | 0.79 | PDE5A (0.54) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL6626598 | 0.78 | PDE5A (0.53) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL16298486 | 0.76 | PDE5A (0.52) | PDE5APDE4AALDH1A1TSHR | |
| SCHEMBL6525072 | 0.72 | PDE5A (0.78) | PDE5A | |
| SCHEMBL6525078 | 0.72 | PDE5A (0.78) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421084-B1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORP (US) | 2008-05-14 | — | — | EP | disclosed |
| EP-1790652-A1 | Polycyclic guanine phosphodiesterase V inhibitors | Schering Corporation (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2003020724-A1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |