Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 13/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16312793 | 0.79 | PDE5A (0.55) | PDE5AALDH1A1TSHRPDE4A | |
| SCHEMBL16298420 | 0.78 | TSHR (0.50) | PDE5AALDH1A1TSHRCYP11B2PDE4A | |
| SCHEMBL235836 | 0.77 | ALDH1A1 (0.54) | PDE5AALDH1A1TSHRCYP11B2PDE4A | |
| SCHEMBL16298468 | 0.76 | PDE5A (0.62) | PDE5AALDH1A1TSHRPDE4A | |
| SCHEMBL234537 | 0.71 | PDE5A (0.65) | PDE5AALDH1A1TSHR | |
| SCHEMBL717262 | 0.71 | PDE5A (0.68) | PDE5A | |
| SCHEMBL234538 | 0.71 | PDE5A (0.65) | PDE5AALDH1A1TSHR | |
| SCHEMBL717261 | 0.71 | PDE5A (0.68) | PDE5A | |
| SCHEMBL16298422 | 0.69 | TSHR (0.50) | PDE5AALDH1A1TSHRCYP11B2 | |
| SCHEMBL11877884 | 0.69 | ALDH1A1 (0.49) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421084-B1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORP (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2003020724-A1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |