Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.66 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.66 |
| ▸ | AR | P10275 | 6/20 | 0.62 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 4/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630955 | 0.90 | PGR (0.68) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL1631083 | 0.87 | PGR (0.51) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL14116473 | 0.85 | PGR (0.53) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL1630385 | 0.84 | PGR (0.66) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL1629404 | 0.84 | PGR (0.58) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL1632652 | 0.84 | PGR (0.69) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL1630067 | 0.84 | PGR (0.65) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL1630669 | 0.84 | PGR (0.64) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL1629418 | 0.83 | PGR (0.63) | PGRNR3C1NR3C2ARIMPDH2 | |
| SCHEMBL1631783 | 0.82 | PGR (0.71) | PGRNR3C1NR3C2ARIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| WO-2007087488-A9 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2008-08-28 | — | — | WO | disclosed |
| WO-2007087488-A2 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-02 | — | — | WO | disclosed |