Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.52 |
| ▸ | TP53 | P04637 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403371 | 0.91 | ABCG2 (0.52) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL765042 | 0.81 | MAPT (0.55) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL8403073 | 0.81 | TP53 (0.57) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL16549469 | 0.80 | ABCG2 (0.65) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL8403214 | 0.80 | MAPT (0.55) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL16549470 | 0.79 | TP53 (0.68) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL8403344 | 0.79 | ABCG2 (0.61) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL764690 | 0.79 | MAPT (0.53) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL11912901 | 0.79 | TP53 (0.64) | ABCG2TP53MAPTSMN1; SMN2ABCB1 | |
| SCHEMBL763565 | 0.78 | LMNA (0.68) | ABCG2TP53MAPTSMN1; SMN2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |