Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403103 | 0.94 | MAPT (0.47) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL8403105 | 0.93 | MAPT (0.46) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL764992 | 0.92 | MEN1 (0.48) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL8403987 | 0.91 | HRH3 (0.48) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL764994 | 0.91 | MEN1 (0.49) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL12981333 | 0.90 | KIF11 (0.45) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL8404039 | 0.90 | HRH3 (0.50) | MAPTTP53SMN1; SMN2KIF11MEN1 | |
| SCHEMBL9962254 | 0.89 | MAPT (0.47) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL10086591 | 0.89 | KIF11 (0.50) | ABCG2MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL8404276 | 0.88 | TP53 (0.48) | ABCG2MAPTLMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |