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Sugi Predict / Compounds / SCHEMBL16300049

SCHEMBL16300049

SCHEMBL16300049

CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCC([C@@H](O[Si](C)(C)C(C)(C)C)c4ccccc4-c4ccc(Cl)cc4)CC3)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ BAD Q92934 1/20 0.67
▸ BCL2L1 Q07817 19/20 0.65
▸ BCL2 P10415 18/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16300840 0.92 BCL2 (0.69) BCL2L1BCL2
SCHEMBL16300048 0.92 BCL2L1 (0.69) BCL2L1BCL2
SCHEMBL554481 0.90 BCL2L1 (0.81) BADBCL2L1BCL2
SCHEMBL554482 0.90 BCL2L1 (0.81) BADBCL2L1BCL2
SCHEMBL554480 0.90 BCL2L1 (0.81) BADBCL2L1BCL2
SCHEMBL553878 0.83 BCL2L1 (0.74) BCL2L1BCL2
SCHEMBL553877 0.83 BCL2L1 (0.74) BCL2L1BCL2
SCHEMBL553879 0.83 BCL2L1 (0.74) BCL2L1BCL2
SCHEMBL554591 0.83 BCL2L1 (0.84) BCL2L1BCL2
SCHEMBL554593 0.83 BCL2L1 (0.84) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012017251-A1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS ASTRAZENECA AB (SE) 2012-02-09 — — WO disclosed
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