Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.54 |
| ▸ | HTR2C | P28335 | 16/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14389998 | 0.89 | HTR2A (0.57) | HTR2AHTR2CHTR2B | |
| SCHEMBL764077 | 0.87 | HTR2A (0.65) | HTR2AHTR2CHTR2B | |
| SCHEMBL16301428 | 0.86 | HTR2C (0.69) | HTR2AHTR2CHTR2B | |
| SCHEMBL29497173 | 0.83 | HTR7 (0.69) | HTR2AHTR2CPRMT5EGFR | |
| SCHEMBL6780834 | 0.83 | HTR7 (0.69) | HTR2AHTR2CPRMT5EGFR | |
| Hydrochloric Acid SCHEMBL18493205 | 0.82 | HTR7 (0.67) | HTR2AHTR2CPRMT5EGFR | |
| SCHEMBL8404356 | 0.82 | HTR2A (0.70) | HTR2AHTR2CHTR2B | |
| SCHEMBL763692 | 0.82 | HTR2A (0.73) | HTR2AHTR2CHTR2B | |
| SCHEMBL8402850 | 0.82 | HTR2A (0.70) | HTR2AHTR2CHTR2B | |
| SCHEMBL8402824 | 0.82 | HTR2A (0.72) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431369-A2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC Therapeutics, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2011150162-A1 | METHODS FOR TREATING VIRAL CONDITIONS | PTC THERAPEUTICS, INC. (US) | 2011-12-01 | — | — | WO | disclosed |
| EP-2298304-A2 | Carboline derivatives useful in the treatment of cancer | PTC Therapeutics, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| US-7767689-B2 | Carboline derivatives useful in the treatment of cancer | PTC THERAPEUTICS, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |