Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.64 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.64 |
| ▸ | AR | P10275 | 6/20 | 0.64 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14472315 | 0.83 | PGR (0.71) | PGRNR3C1NR3C2ARCYP17A1 | |
| SCHEMBL1631091 | 0.82 | PGR (0.73) | PGRNR3C1NR3C2ARCYP17A1 | |
| SCHEMBL14116612 | 0.82 | PGR (0.75) | PGRNR3C1NR3C2ARCYP17A1 | |
| SCHEMBL1629887 | 0.82 | PGR (0.72) | PGRNR3C1NR3C2ARCYP17A1 | |
| SCHEMBL1629914 | 0.81 | PGR (0.70) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1630932 | 0.81 | PGR (0.65) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1631200 | 0.79 | PGR (1.00) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1629666 | 0.79 | PGR (0.68) | PGRNR3C1NR3C2ARCYP17A1 | |
| SCHEMBL1630660 | 0.78 | PGR (0.67) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630569 | 0.78 | PGR (0.69) | PGRNR3C1NR3C2ARKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |