Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 11/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ADCY6 | O43306 | 3/20 | 0.49 |
| ▸ | ADCY3 | O60266 | 3/20 | 0.49 |
| ▸ | ADCY9 | O60503 | 3/20 | 0.49 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.49 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.49 |
| ▸ | ADCY7 | P51828 | 3/20 | 0.49 |
| ▸ | ADCY2 | Q08462 | 3/20 | 0.49 |
| ▸ | ADCY1 | Q08828 | 3/20 | 0.49 |
| ▸ | ADCY4 | Q8NFM4 | 3/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16305379 | 1.00 | GCGR (0.52) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16305835 | 1.00 | GCGR (0.52) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16306221 | 0.99 | GCGR (0.53) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16305377 | 0.97 | GCGR (0.53) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16306177 | 0.93 | L3MBTL1 (0.55) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16305695 | 0.92 | GCGR (0.52) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16306220 | 0.91 | GCGR (0.56) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16306176 | 0.91 | GCGR (0.51) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL15019651 | 0.91 | GCGR (0.52) | GCGRL3MBTL1ADCY6ADCY3ADCY9 | |
| SCHEMBL16380079 | 0.91 | GCGR (0.52) | GCGRL3MBTL1ADCY6ADCY3ADCY9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008056-B1 | NOVEL GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-12-09 | — | — | EP | disclosed |
| US-10259823-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2019-04-16 | — | — | US | disclosed |
| US-10034886-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2018-07-31 | — | — | US | disclosed |
| US-10034886-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2018-07-31 | — | — | US | disclosed |
| US-20170313717-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2017-11-02 | — | — | US | disclosed |
| US-9795613-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2017-10-24 | — | — | US | disclosed |
| US-9795613-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2017-10-24 | — | — | US | disclosed |
| US-20160214993-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2016-07-28 | — | — | US | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |
| US-20150011527-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2015-01-08 | — | — | US | disclosed |
| WO-2014201172-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS, INC. (US) | 2014-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313717-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | GCGR 4/4885L3MBTL1 771/4885ADCY6 323/4885 |
| US-20160214993-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | GCGR 4/4885L3MBTL1 771/4885ADCY6 323/4885 |
| US-10034886-B2 | GLP-1 receptor modulators | GLP1R, GIPR, GCGR | GCGR 3/4885L3MBTL1 579/4885ADCY6 411/4885 |
| US-10259823-B2 | GLP-1 receptor modulators | GLP1R, GIPR, GCGR | GCGR 3/4885L3MBTL1 579/4885ADCY6 411/4885 |
| US-20150011527-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | GCGR 4/4885L3MBTL1 771/4885ADCY6 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.