Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.61 |
| ▸ | TYMS | P04818 | 15/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19992101 | 0.86 | PARP1 (0.66) | PARP1TYMSTNKS2ALDH1A1 | |
| SCHEMBL19992061 | 0.83 | PARP1 (0.62) | PARP1TYMSTNKS2ALDH1A1 | |
| SCHEMBL24879353 | 0.83 | PARP1 (0.58) | PARP1TYMSTNKS2ALDH1A1 | |
| SCHEMBL23229338 | 0.83 | PARP1 (0.58) | PARP1TYMSTNKS2ALDH1A1 | |
| SCHEMBL9518147 | 0.82 | PARP1 (0.64) | PARP1TYMSTNKS2 | |
| SCHEMBL7826334 | 0.79 | PARP1 (0.60) | PARP1TYMSTNKS2 | |
| SCHEMBL19992076 | 0.79 | PARP1 (0.66) | PARP1TYMSTNKS2ALDH1A1 | |
| SCHEMBL19992074 | 0.77 | PARP1 (0.62) | PARP1TYMSTNKS2ALDH1A1 | |
| SCHEMBL12169915 | 0.76 | PARP1 (1.00) | PARP1TYMSTNKS2 | |
| SCHEMBL30704850 | 0.76 | PARP1 (1.00) | PARP1TYMSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935246-B1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-3008053-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2014201409-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-12-18 | — | — | WO | disclosed |