Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.56 |
| ▸ | AR | P10275 | 6/20 | 0.56 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 4/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | PRF1 | P14222 | 1/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1629525 | 0.89 | PGR (0.60) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL1629526 | 0.89 | PGR (0.60) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL1630771 | 0.82 | PGR (0.57) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL1630955 | 0.81 | PGR (0.68) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL14116513 | 0.74 | PGR (0.76) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL14116616 | 0.74 | PGR (0.76) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL14472024 | 0.74 | PGR (0.58) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL14472027 | 0.74 | PGR (0.58) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL1629404 | 0.73 | PGR (0.58) | PGRNR3C1NR3C2ARKAT2B | |
| SCHEMBL1629654 | 0.73 | PGR (0.66) | PGRNR3C1NR3C2ARKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090069400-A1 | Indole Sulfonamide Modulators of Progesterone Receptors | ELI LILLY AND COMPANY | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069400-A1 | Indole Sulfonamide Modulators of Progesterone Receptors | PGR, NPSR1, PRLHR | PGR 1/4885NR3C1 63/4885NR3C2 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.