Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308114 | 0.88 | PIK3CB (0.38) | MMP7MMP12MMP3MMP10MMP8 | |
| SCHEMBL15029883 | 0.87 | P2RY12 (0.37) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL16308096 | 0.87 | GPR119 (0.39) | MMP7MMP12MMP3MMP10PIK3CB | |
| SCHEMBL16308253 | 0.85 | PIK3CB (0.54) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15009071 | 0.85 | PIK3CB (0.41) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL10124148 | 0.85 | PIK3CB (0.41) | PIK3CBPIK3CDPIK3CAPIK3CGOPRM1 | |
| SCHEMBL15009709 | 0.84 | PIK3CB (0.40) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL16308085 | 0.84 | ALOX5AP (0.42) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL16308048 | 0.82 | CHEK2 (0.41) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL16308251 | 0.81 | PIK3CB (0.52) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |