Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308116 | 0.89 | PIK3CB (0.53) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL16308153 | 0.89 | PIK3CA (0.48) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL16308155 | 0.86 | TGFBR1 (0.42) | PIK3CAPIK3CBPIK3CDPIK3R1TGFBR1 | |
| SCHEMBL16308133 | 0.85 | PIK3CB (0.49) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL16308158 | 0.85 | PIK3CB (0.51) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL16308156 | 0.85 | PIK3CB (0.51) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL16308097 | 0.84 | TGFBR1 (0.42) | PIK3CAPIK3CBPIK3CDPIK3R1TGFBR1 | |
| SCHEMBL16308159 | 0.83 | TGFBR1 (0.43) | PIK3CAPIK3CBPIK3CDPIK3R1TGFBR1 | |
| SCHEMBL16308171 | 0.83 | PIK3CB (0.51) | PIK3CAPIK3CBPIK3CDPIK3R1NAPEPLD | |
| SCHEMBL16308176 | 0.83 | PIK3CB (0.51) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |