Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 7/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.45 |
| ▸ | ATR | Q13535 | 6/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.43 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308205 | 1.00 | PDCD1 (0.51) | PDCD1CD274PIK3CBATRPIK3CD | |
| SCHEMBL16308139 | 0.91 | PDCD1 (0.56) | PDCD1CD274PIK3CBATRPIK3CD | |
| SCHEMBL15029333 | 0.91 | PDCD1 (0.56) | PDCD1CD274PIK3CBATRPIK3CD | |
| SCHEMBL17529191 | 0.89 | PIK3CB (0.59) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17529190 | 0.89 | PIK3CB (0.59) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL10125153 | 0.86 | PDCD1 (0.54) | PDCD1CD274PIK3CBATRPIK3CD | |
| SCHEMBL10125156 | 0.86 | PDCD1 (0.54) | PDCD1CD274PIK3CBATRPIK3CD | |
| SCHEMBL10125164 | 0.85 | PDCD1 (0.53) | PDCD1CD274PIK3CBATRPIK3CD | |
| SCHEMBL10125222 | 0.85 | PDCD1 (0.53) | PDCD1CD274PIK3CBATRPIK3CD | |
| SCHEMBL13247962 | 0.85 | PDCD1 (0.53) | PDCD1CD274PIK3CBATRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604601-B1 | HETERO RING COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |