Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 10/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | PAK3 | O75914 | 2/20 | 0.39 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041507 | 0.83 | TNK2 (0.44) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL15036026 | 0.83 | TNK2 (0.44) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL16309192 | 0.82 | TNK2 (0.46) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL16310842 | 0.81 | TNK2 (0.41) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL13554015 | 0.75 | PAK1 (0.59) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL14681996 | 0.75 | TNK2 (0.43) | TNK2PKN1PAK4WEE1 | |
| Hydrochloric Acid SCHEMBL1681161 | 0.75 | PAK1 (0.58) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL15035853 | 0.74 | WEE1 (0.38) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL15041504 | 0.74 | PKN1 (0.40) | TNK2PKN1PAK4WEE1PAK1 | |
| SCHEMBL16309185 | 0.74 | RIPK2 (0.41) | TNK2WEE1FGFR1RIPK2NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |