Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 16/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036098 | 0.91 | TNK2 (0.47) | TNK2PAK4PKN1PAK1WEE1 | |
| SCHEMBL15041504 | 0.82 | PKN1 (0.40) | TNK2PAK4PKN1PAK1WEE1 | |
| SCHEMBL16309178 | 0.82 | TNK2 (0.43) | TNK2PAK4PKN1PAK1WEE1 | |
| SCHEMBL16309182 | 0.81 | PAK4 (0.48) | TNK2PAK4PKN1PAK1JAK3 | |
| SCHEMBL13553839 | 0.78 | PAK1 (0.42) | TNK2PAK4PKN1PAK1WEE1 | |
| SCHEMBL15041668 | 0.76 | CDK4 (0.37) | TNK2PAK4PKN1 | |
| SCHEMBL16309174 | 0.75 | PAK1 (0.43) | TNK2PAK1 | |
| SCHEMBL15036151 | 0.74 | PAK4 (0.50) | TNK2PAK4PKN1JAK3 | |
| SCHEMBL13554015 | 0.74 | PAK1 (0.59) | TNK2PAK4PKN1PAK1WEE1 | |
| SCHEMBL15785369 | 0.74 | PKN1 (0.43) | TNK2PAK4PKN1PAK1WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |