Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15281139 | 0.92 | TNK2 (0.44) | CAMK2DTNK2SRCRIPK2ACVR1 | |
| SCHEMBL15036142 | 0.88 | CAMK2D (0.43) | CAMK2DTNK2SRCRIPK2ACVR1 | |
| SCHEMBL13553920 | 0.79 | CAMK2D (0.43) | CAMK2DTNK2SRCRIPK2ACVR1 | |
| SCHEMBL15041481 | 0.78 | CAMK2D (0.43) | CAMK2DTNK2SRCRIPK2ACVR1 | |
| SCHEMBL14681967 | 0.78 | PAK3 (0.45) | CAMK2DTNK2SRCRIPK2ACVR1 | |
| SCHEMBL15785313 | 0.76 | FGFR1 (0.46) | CAMK2DTNK2SRCRIPK2ACVR1 | |
| SCHEMBL14682044 | 0.76 | CAMK2D (0.42) | CAMK2DTNK2SRCRIPK2ACVR1 | |
| SCHEMBL15041898 | 0.75 | RIPK2 (0.41) | CAMK2DTNK2RIPK2ACVR1NOD2 | |
| SCHEMBL15036004 | 0.74 | CDK4 (0.38) | RIPK2ACVR1NOD2FGFR1FGFR2 | |
| SCHEMBL15041484 | 0.74 | FGFR1 (0.44) | CAMK2DTNK2SRCRIPK2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |