Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 16/20 | 0.46 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16309464 | 0.87 | GRM5 (0.44) | GRM5GRM3 | |
| SCHEMBL16309496 | 0.87 | GRM5 (0.61) | GRM5 | |
| SCHEMBL16309611 | 0.86 | GRM5 (0.44) | GRM5GRM3 | |
| SCHEMBL16309429 | 0.85 | GRM5 (0.42) | GRM5GRM3 | |
| SCHEMBL16309446 | 0.85 | TP53 (0.45) | GRM5GRM3 | |
| SCHEMBL16309485 | 0.85 | GRM5 (0.53) | GRM5 | |
| SCHEMBL16309437 | 0.85 | GRM5 (0.53) | GRM5 | |
| SCHEMBL16704469 | 0.84 | GRM5 (0.59) | GRM5 | |
| SCHEMBL16309395 | 0.84 | ALDH1A1 (0.47) | GRM5GRM3 | |
| SCHEMBL16309432 | 0.84 | GRM5 (0.42) | GRM5GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | UNIV VANDERBILT (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | UNIV VANDERBILT (US) | 2015-08-06 | — | — | US | disclosed |
| US-9029366-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029366-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2013192346-A9 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2014-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM3 | ENPP2 1236/4885GRM5 1/4885GRM3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.