Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308879 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9AALDH1A1NPC1NPSR1 | |
| Hydrochloric Acid SCHEMBL16286916 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9AALDH1A1NPC1NPSR1 | |
| SCHEMBL279957 | 0.79 | KMT2A (0.86) | SMN1; SMN2RAB9AALDH1A1NPC1NPSR1 | |
| SCHEMBL11918653 | 0.79 | KMT2A (0.86) | SMN1; SMN2RAB9AALDH1A1NPC1NPSR1 | |
| SCHEMBL8404634 | 0.77 | MEN1 (0.59) | SMN1; SMN2CYP1A2HPGDHTTTP53 | |
| SCHEMBL14368076 | 0.77 | MEN1 (0.59) | SMN1; SMN2CYP1A2HPGDHTTTP53 | |
| SCHEMBL12880452 | 0.77 | MEN1 (0.59) | SMN1; SMN2CYP1A2HPGDHTTTP53 | |
| SCHEMBL16286948 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AALDH1A1NPC1NPSR1 | |
| SCHEMBL14297340 | 0.76 | KDM4E (0.76) | SMN1; SMN2RAB9AALDH1A1NPC1NPSR1 | |
| SCHEMBL16286770 | 0.76 | UBE2N (0.47) | SMN1; SMN2RAB9AALDH1A1NPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409876-B2 | Bradykinin receptor antagonists and pharmaceutical compositions containing them | DOMPE' FARMACEUTICI S.P.A. (IT) | 2016-08-09 | — | — | US | disclosed |
| US-20140371274-A1 | BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' FARMACEUTICI S.P.A. (IT) | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371274-A1 | BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BDKRB1, BDKRB2, EDNRB | SMN1; SMN2 3999/4885RAB9A 2576/4885ALDH1A1 4192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.