Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 20/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 13/20 | 0.48 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16359483 | 0.93 | OPRD1 (0.50) | OPRD1KCNH2CYP2D6MRGPRX2OPRM1 | |
| SCHEMBL471474 | 0.88 | OPRD1 (0.48) | OPRD1KCNH2CYP2D6MRGPRX2 | |
| SCHEMBL16315264 | 0.83 | OPRD1 (0.51) | OPRD1KCNH2CYP2D6OPRM1 | |
| SCHEMBL12262199 | 0.83 | OPRD1 (0.48) | OPRD1KCNH2CYP2D6MRGPRX2 | |
| SCHEMBL471472 | 0.78 | OPRD1 (0.52) | OPRD1KCNH2CYP2D6MRGPRX2OPRM1 | |
| SCHEMBL10257763 | 0.76 | OPRD1 (0.55) | OPRD1KCNH2CYP2D6MRGPRX2OPRM1 | |
| SCHEMBL16315260 | 0.76 | OPRD1 (0.43) | OPRD1KCNH2CYP2D6OPRM1 | |
| SCHEMBL467355 | 0.76 | OPRD1 (0.72) | OPRD1KCNH2CYP2D6MRGPRX2OPRM1 | |
| SCHEMBL12262138 | 0.74 | OPRD1 (0.65) | OPRD1KCNH2CYP2D6OPRM1 | |
| SCHEMBL471361 | 0.74 | OPRD1 (0.67) | OPRD1KCNH2CYP2D6MRGPRX2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399577-A1 | Use of N-containing spirocompounds for the enhancement of cognitive function | Adolor Corporation (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2008033299-A2 | USE OF N-CONTAINING SPIROCOMPOUNDS FOR THE ENHANCEMENT OF COGNITIVE FUNCTION | ADOLOR CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |