Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | WHR1 | P49842 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14438925 | 0.89 | MAPK14 (0.59) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL296765 | 0.84 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL1942916 | 0.82 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL296279 | 0.79 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| Hydrochloric Acid SCHEMBL296658 | 0.78 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL6778879 | 0.78 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL371380 | 0.78 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL2838827 | 0.78 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL297387 | 0.78 | PDE4A (0.87) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL1943209 | 0.78 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191336-A1 | p38 kinase inhibitors | DECIPHERA PHARMACEUTICALS, LLC | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191336-A1 | p38 kinase inhibitors | MAPK1, MAP3K8, MAP3K1 | PDE4A 1042/4885PDE4B 1446/4885PDE4C 1171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.