Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.59 |
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 2/20 | 0.48 |
| ▸ | WHR1 | P49842 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16317175 | 0.89 | PDE4A (0.62) | MAPK14EGFRMEN1KMT2ARXFP1 | |
| SCHEMBL13296171 | 0.84 | PDE4A (0.67) | MAPK14EGFRMEN1KMT2ARXFP1 | |
| Diphenylamine SCHEMBL8885083 | 0.74 | ABCG2 (0.55) | EGFRSMN1; SMN2PDE4APDE4DWHR1 | |
| SCHEMBL296765 | 0.73 | PDE4A (0.85) | MAPK14EGFRMEN1KMT2ARXFP1 | |
| SCHEMBL6781371 | 0.71 | MAPK14 (0.76) | MAPK14EGFRMEN1KMT2APOLB | |
| SCHEMBL4564291 | 0.71 | PDE4A (0.49) | MAPK14EGFRMEN1KMT2ARXFP1 | |
| SCHEMBL1942916 | 0.71 | PDE4A (0.76) | MAPK14EGFRMEN1KMT2ARXFP1 | |
| SCHEMBL4138117 | 0.70 | PDE4A (0.58) | MEN1KMT2ARXFP1PDE4APDE4D | |
| SCHEMBL1520202 | 0.70 | F10 (0.63) | MAPK14MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL16315856 | 0.69 | PDE4A (0.67) | MAPK14EGFRMEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191336-A1 | p38 kinase inhibitors | DECIPHERA PHARMACEUTICALS, LLC | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191336-A1 | p38 kinase inhibitors | MAPK1, MAP3K8, MAP3K1 | MAPK14 29/4885EGFR 2425/4885MEN1 4811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.