SCHEMBL16319241

SCHEMBL16319241

CCOc1cc(C)ccc1Oc1cc(F)c(C(=O)NS(C)(=O)=O)cc1F

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.54
SCN5A Q14524 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16319340 0.88 SCN9A (0.57) SCN9ASCN5A
SCHEMBL679961 0.88 SCN9A (0.57) SCN9ASCN5A
SCHEMBL16319360 0.87 SCN9A (0.62) SCN9ASCN5A
SCHEMBL16319633 0.85 SCN9A (0.57) SCN9ASCN5A
SCHEMBL363461 0.85 SCN9A (0.60) SCN9A
SCHEMBL16319614 0.83 SCN9A (0.70) SCN9ASCN5A
SCHEMBL680347 0.82 SCN9A (0.68) SCN9ASCN5A
SCHEMBL681086 0.80 SCN9A (0.58) SCN9ASCN5A
SCHEMBL680082 0.80 SCN9A (0.72) SCN9ASCN5A
SCHEMBL22067283 0.80 KCNMA1 (0.48) SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593427-B1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LTD (GB) 2014-12-24 EP disclosed