SCHEMBL16319394

SCHEMBL16319394

COc1cc(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)cc1C(=O)NS(C)(=O)=O

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.66
SCN5A Q14524 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16319537 0.92 SCN9A (0.78) SCN9ASCN5A
SCHEMBL16319431 0.92 SCN9A (0.68) SCN9ASCN5A
SCHEMBL365203 0.87 SCN9A (0.60) SCN9ASCN5A
SCHEMBL680222 0.86 SCN9A (0.63) SCN9ASCN5A
SCHEMBL369786 0.85 SCN9A (0.81) SCN9ASCN5A
SCHEMBL16319564 0.84 SCN9A (0.56) SCN9ASCN5A
SCHEMBL680215 0.84 SCN9A (0.69) SCN9ASCN5A
SCHEMBL16319499 0.83 SCN9A (0.63) SCN9ASCN5A
SCHEMBL16319777 0.83 SCN9A (0.78) SCN9ASCN5A
SCHEMBL16319584 0.83 SCN9A (0.60) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593427-B1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LTD (GB) 2014-12-24 EP disclosed