Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319560 | 0.94 | SCN9A (0.41) | SCN9ALMNA | |
| SCHEMBL365466 | 0.92 | SCN9A (0.46) | SCN9ALMNAMEN1KMT2ANPSR1 | |
| SCHEMBL16319602 | 0.86 | SCN9A (0.44) | SCN9ALMNAMEN1KMT2AMAPT | |
| SCHEMBL685592 | 0.85 | SCN9A (0.51) | SCN9ALMNAMEN1KMT2ANPSR1 | |
| SCHEMBL364739 | 0.80 | SCN9A (0.51) | SCN9ALMNA | |
| SCHEMBL365478 | 0.79 | SCN9A (0.52) | SCN9A | |
| SCHEMBL16319490 | 0.78 | SCN9A (0.77) | SCN9A | |
| SCHEMBL365104 | 0.77 | SCN9A (0.44) | SCN9ALMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL16175597 | 0.77 | SCN9A (0.47) | SCN9A | |
| SCHEMBL1690158 | 0.77 | SCN9A (0.49) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |