Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365466 | 0.95 | SCN9A (0.46) | SCN9ALMNAMEN1ALDH1A1MAPT | |
| SCHEMBL16319560 | 0.93 | SCN9A (0.41) | SCN9ALMNA | |
| SCHEMBL364739 | 0.88 | SCN9A (0.51) | SCN9ALMNA | |
| SCHEMBL16319395 | 0.86 | SCN9A (0.46) | SCN9ALMNAMEN1MAPTKMT2A | |
| SCHEMBL16175597 | 0.86 | SCN9A (0.47) | SCN9A | |
| SCHEMBL366078 | 0.85 | SCN9A (0.61) | SCN9ALMNA | |
| SCHEMBL680124 | 0.83 | SCN9A (0.51) | SCN9ALMNA | |
| SCHEMBL365478 | 0.82 | SCN9A (0.52) | SCN9A | |
| SCHEMBL365174 | 0.80 | SCN9A (0.61) | SCN9A | |
| SCHEMBL16175104 | 0.80 | SCN9A (0.49) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |