Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 11/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | ESRRA | P11474 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11189002 | 0.90 | AR (0.58) | ARSLC6A4POLBGAASLC22A12 | |
| SCHEMBL363575 | 0.88 | AR (0.51) | ARSLC6A4SLC22A12 | |
| SCHEMBL4857820 | 0.86 | AR (0.53) | ARSLC6A4KDM4EUSP2ALDH1A1 | |
| SCHEMBL15094069 | 0.82 | AR (0.66) | ARSLC6A4ESRRAKDM4EALDH1A1 | |
| SCHEMBL5341215 | 0.81 | AR (0.46) | ARESRRAPOLBGAAKDM4E | |
| SCHEMBL5343220 | 0.81 | ALDH1A1 (0.52) | ARESRRAPOLBGAAALDH1A1 | |
| SCHEMBL5344036 | 0.80 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5344013 | 0.80 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL29615609 | 0.79 | ALDH1A1 (0.61) | ARSLC6A4KDM4EUSP2ALDH1A1 | |
| SCHEMBL945003 | 0.79 | ALDH1A1 (0.61) | ARSLC6A4KDM4EUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |