Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.74 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.55 |
| ▸ | SCN2B | O60939 | 1/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319835 | 0.91 | SCN9A (0.74) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16319547 | 0.87 | SCN9A (0.68) | SCN9ASCN5ASCN1A | |
| SCHEMBL679353 | 0.87 | SCN9A (0.68) | SCN9ASCN5A | |
| SCHEMBL680467 | 0.86 | SCN9A (0.72) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16319598 | 0.85 | SCN9A (1.00) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16319565 | 0.85 | SCN9A (0.71) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL371284 | 0.84 | SCN9A (0.77) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16319834 | 0.84 | SCN9A (0.80) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16319304 | 0.84 | SCN9A (0.58) | SCN9ASCN5A | |
| SCHEMBL16319797 | 0.84 | SCN9A (0.69) | SCN9ASCN5ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |