Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498327 | 0.93 | IKBKB (0.43) | IKBKBSYKJAK2JAK1JAK3 | |
| SCHEMBL1634175 | 0.91 | SYK (0.53) | IKBKBSYKJAK2JAK1JAK3 | |
| SCHEMBL1635190 | 0.91 | SYK (0.49) | IKBKBSYKJAK2JAK1JAK3 | |
| SCHEMBL1634267 | 0.86 | CDK4 (0.50) | EGFRIGF1RAURKABRD4 | |
| SCHEMBL1633616 | 0.86 | IKBKB (0.48) | IKBKBSYKJAK2JAK1JAK3 | |
| SCHEMBL1633269 | 0.86 | IKBKB (0.48) | IKBKBSYKJAK2JAK1JAK3 | |
| SCHEMBL1634242 | 0.84 | HRH3 (0.44) | SYKBRD4 | |
| SCHEMBL1633642 | 0.84 | MAP3K5 (0.48) | IKBKBSYKJAK2JAK1JAK3 | |
| SCHEMBL1633588 | 0.84 | WEE1 (0.43) | BRD4 | |
| SCHEMBL12193071 | 0.82 | IKBKB (0.48) | IKBKBEGFRPRKCZROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |