Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | CDK7 | P50613 | 4/20 | 0.42 |
| ▸ | CCNH | P51946 | 4/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.42 |
| ▸ | CCNK | O75909 | 3/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND3 | P30281 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634267 | 0.89 | CDK4 (0.50) | CCNA2CDK2BRD4CDK4CCND1 | |
| SCHEMBL1634242 | 0.86 | HRH3 (0.44) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL1632083 | 0.84 | IKBKB (0.47) | BRD4 | |
| SCHEMBL12724903 | 0.83 | CDK4 (0.47) | CCNA2CDK2BRD4CDK4CCND1 | |
| SCHEMBL12724898 | 0.81 | HRH3 (0.43) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL2476354 | 0.79 | HRH3 (0.44) | CCNA2CDK2CDK7CCNHMNAT1 | |
| SCHEMBL1632964 | 0.78 | USP2 (0.49) | CCNA2CDK2BRD4LMNA | |
| SCHEMBL13498327 | 0.78 | IKBKB (0.43) | CHEK1BRD4FGFR1FGFR4KDR | |
| SCHEMBL1635190 | 0.76 | SYK (0.49) | CDK2CHEK1KDRCDK4 | |
| SCHEMBL1634175 | 0.75 | SYK (0.53) | CCNA2CDK2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |