Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634161 | 0.92 | FGFR2 (0.42) | MAPK10FGFR2JUNBRAFJAK2 | |
| SCHEMBL12724595 | 0.90 | MAPK10 (0.45) | MAPK10FGFR2JUNBRAFMAPK8 | |
| SCHEMBL1631671 | 0.87 | MAPK10 (0.44) | MAPK10FGFR2JUNBRAFMAPK8 | |
| SCHEMBL1632441 | 0.87 | MAPK10 (0.48) | MAPK10FGFR2JUNBRAFMAPK8 | |
| SCHEMBL1631175 | 0.86 | FGFR2 (0.45) | MAPK10FGFR2JUNBRAFMAPK8 | |
| SCHEMBL1634890 | 0.86 | MAPK10 (0.47) | MAPK10FGFR2JUNBRAFMAPK8 | |
| SCHEMBL1632922 | 0.85 | JAK2 (0.48) | MAPK10FGFR2JUNMAPK8JAK2 | |
| SCHEMBL1634397 | 0.85 | MAPK10 (0.59) | MAPK10FGFR2JUNBRAFMAPK8 | |
| SCHEMBL1633503 | 0.85 | MAPK10 (0.47) | MAPK10FGFR2JUNBRAFMAPK8 | |
| SCHEMBL13498285 | 0.84 | MAPK10 (0.47) | MAPK10FGFR2JUNBRAFMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |