Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.41 |
| ▸ | JUN | P05412 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632137 | 0.92 | MAPK10 (0.46) | FGFR2MAPK10JUNEGFRJAK2 | |
| SCHEMBL13498338 | 0.87 | SYK (0.43) | MAPK10JUNPTK2AURKANEK2 | |
| SCHEMBL1631565 | 0.84 | MAPK10 (0.48) | FGFR2MAPK10JUNCDK4JAK2 | |
| SCHEMBL1634890 | 0.84 | MAPK10 (0.47) | FGFR2MAPK10JUNJAK2BRD4 | |
| SCHEMBL1633636 | 0.84 | RIPK2 (0.48) | FGFR2MAPK10JUNPTK2JAK2 | |
| SCHEMBL1633364 | 0.84 | KDR (0.45) | FGFR2MAPK10JUNCDK4KDR | |
| SCHEMBL1633229 | 0.84 | TBK1 (0.49) | MAPK10PTK2AURKAEGFRJAK2 | |
| SCHEMBL1632057 | 0.83 | GBA1 (0.45) | FGFR2MAPK10JUNPTK2EGFR | |
| SCHEMBL12724595 | 0.83 | MAPK10 (0.45) | FGFR2MAPK10JUNEGFRJAK2 | |
| SCHEMBL1632441 | 0.82 | MAPK10 (0.48) | FGFR2MAPK10JUNEGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |