Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.49 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NPM1 | P06748 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGR | P09769 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12725070 | 0.91 | MAP4K1 (0.47) | MAP4K1MAP3K5ROCK2LCKKDR | |
| SCHEMBL1632123 | 0.91 | MAP3K5 (0.44) | MAP4K1MAP3K5ROCK2LCKSYK | |
| SCHEMBL1633840 | 0.82 | MAP3K5 (0.40) | MAP4K1MAP3K5ROCK2LCKSYK | |
| SCHEMBL12725033 | 0.80 | MAP3K5 (0.44) | MAP4K1MAP3K5ROCK2LCKSYK | |
| SCHEMBL1633561 | 0.79 | MAP4K1 (0.42) | MAP4K1ROCK2LCKKDRMAPK14 | |
| SCHEMBL1633572 | 0.79 | MAP4K1 (0.53) | MAP4K1SRCJAK2PDGFRBFGFR1 | |
| SCHEMBL1872204 | 0.78 | MAP3K5 (0.60) | MAP4K1MAP3K5ROCK2FGFR1BRAF | |
| SCHEMBL12725036 | 0.72 | MAP3K5 (0.39) | MAP4K1MAP3K5ROCK2LCKSYK | |
| SCHEMBL1633838 | 0.71 | MAPK10 (0.51) | MAP4K1JAK2PDGFRBPDGFRAJAK3 | |
| SCHEMBL1634531 | 0.71 | SYK (0.47) | ROCK2SYKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |