Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCND3 | P30281 | 2/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634531 | 0.92 | SYK (0.47) | JUNMAPK8MAPK10EPHB4SYK | |
| SCHEMBL1633572 | 0.87 | MAP4K1 (0.53) | MAP4K1JUNMAPK8MAPK10CDK4 | |
| SCHEMBL1633457 | 0.86 | EGFR (0.40) | MAP4K1JUNMAPK8MAPK10EPHB4 | |
| SCHEMBL1633334 | 0.82 | SYK (0.46) | MAPK10EPHB4SYKRIPK2TBK1 | |
| SCHEMBL1633838 | 0.79 | MAPK10 (0.51) | MAP4K1JUNMAPK8MAPK10CDK4 | |
| SCHEMBL1571608 | 0.79 | SYK (0.47) | JUNMAPK8MAPK10EPHB4SYK | |
| SCHEMBL1632182 | 0.79 | MAP4K1 (0.49) | MAP4K1SYKLCKKDRMAPK14 | |
| SCHEMBL1633459 | 0.79 | SYK (0.46) | JUNMAPK8MAPK10EPHB4SYK | |
| SCHEMBL1634307 | 0.79 | MAPK10 (0.55) | MAP4K1JUNMAPK8MAPK10SYK | |
| SCHEMBL12725070 | 0.78 | MAP4K1 (0.47) | MAP4K1SYKLCKKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |