Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.66 |
| ▸ | PLD2 | O14939 | 1/20 | 0.63 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NHERF1 | O14745 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.50 |
| ▸ | PYGL | P06737 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12392536 | 0.89 | PLD2 (0.53) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL15224002 | 0.89 | EGFR (0.52) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL15223912 | 0.88 | EGFR (0.67) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL13941702 | 0.84 | EGFR (0.48) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL13941524 | 0.84 | PLK4 (0.51) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL15623149 | 0.83 | PLD2 (0.70) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL15223750 | 0.81 | EGFR (0.68) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL15652456 | 0.81 | HDAC2 (0.76) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL15223913 | 0.80 | EGFR (0.56) | EGFRPIK3CAPLD2PLD1HDAC2 | |
| SCHEMBL12848230 | 0.78 | PLD2 (0.63) | EGFRPIK3CAPLD2PLD1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170333567-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | SYNTARGA BV (NL) | 2017-11-23 | — | — | US | disclosed |
| US-9815784-B2 | CC-1065 analogs and their conjugates | SYNTARGA B.V. (NL) | 2017-11-14 | — | — | US | disclosed |
| US-20170274090-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | SYNTARGA BV (NL) | 2017-09-28 | — | — | US | disclosed |
| US-20110207767-A1 | Novel cc-1065 Analogs and Their Conjugates | BYONDIS B.V. (NL) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170274090-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | PCNA, DCLRE1A, CDC5L | EGFR 1166/4885PIK3CA 3395/4885PLD2 1947/4885 |
| US-20170333567-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | PCNA, DCLRE1A, CDC5L | EGFR 1166/4885PIK3CA 3395/4885PLD2 1947/4885 |
| US-20110207767-A1 | Novel cc-1065 Analogs and Their Conjugates | PCNA, CDC5L, TOP1 | EGFR 1116/4885PIK3CA 2910/4885PLD2 2426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.